The amount of Cellcept 500mg Tablet you take and how often you take it depends on the type of transplant you have. Follow your doctor’s instructions on this. You should take it on an empty stomach, at least 1 hour before or 2 hours after a meal. Swallow it as a whole, do not crush, chew, or break it. Take the medicine regularly to get the maximum benefit and keep taking it even if you feel well. If you stop taking it, you may increase the chances of rejecting your transplanted organ. The treatment will continue for as long as you need it to prevent rejection.